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INDICATIONS
If you or someone you know has
been diagnosed with DVT/PE, it’s
understandable
that you may have
questions. Here are some answers to help
you know more about
the condition,
the role of blood thinners, and ELIQUIS.
DVT is a blood clot in a deep vein—usually in the leg, thigh, or pelvis, but they can also occur in
the arm—that limits the flow of blood in veins. Sometimes a DVT blood clot can break free and
travel to the lungs. This is known as a PE. A PE blood clot can limit the flow of blood in the lungs
and can even cause sudden death. DVT and PE can happen more than once.
To learn more, watch the video below.
What Are
DVT and PE?
Both DVT and PE are fairly common. In 2010, it was estimated that each year there are as many as 900,000 adults in the U.S. with DVT/PE. About one third of DVT/PE events are PE.
DVT and PE are a public health concern:
PE can cause sudden death in about 25% of cases
Up to 100,000 patients in the U.S. are estimated to die due to DVT/PE each year
Within 1 month of diagnosis, 10% – 30% of patients die due to DVT/PE
Pulmonary embolism (PE): The most serious risk from DVT is PE. A PE clot can limit the flow of blood in the lungs and can even cause sudden death.
DVT and/or PE can happen more than once. About 33% of patients with DVT or PE have a recurrence within 10 years of their first DVT or PE.
To learn more, watch the video below.
What Is the
Risk of DVT/PE
happening
again?
Doctors may use multiple tests to find out if you have DVT or PE.
Usually, a diagnosis of DVT and/or PE is based upon:
Medical history: Includes questions about your overall health and any prescription medicines you’re taking.
Physical exam: A doctor will examine your legs for signs of DVT and evaluate your blood pressure, your heart, and your lungs.
Test results: Certain tests can help diagnose DVT and PE. Some of the common ones include:
Ultrasound: Doctors can use ultrasound to look for blood clots in your legs and pelvis. Ultrasound uses sound waves to check blood flow in your veins
CT scans: The test uses X-rays and allows doctors to detect most cases of PE
D-dimer test: A blood test that measures a substance in the blood that’s released when a blood clot dissolves
The most common DVT treatments and PE treaments are anticoagulants, otherwise known as
blood thinners. Blood thinners treat deep vein thrombosis (DVT) and pulmonary embolism (PE) by
reducing the ability of the blood to clot and reducing the risk of further clots developing.
Here are some commonly prescribed blood thinners for DVT/PE and some of the differences
between them. You can also
learn about the clinical trials that compared ELIQUIS with
LOVENOX® (enoxaparin)
followed by warfarin.
LOVENOX® (enoxaparin) is a blood thinner that is only available in injectable form.
Warfarin is a pill that’s taken orally. Patients taking warfarin have to follow certain dietary
restrictions. Warfarin also requires patients to go for routine INR blood testing to check if their
levels are within the target range and to adjust their warfarin dose if they’re not.
DOACs (direct-acting oral anticoagulants), including ELIQUIS, are blood thinners that can help
treat DVT and PE clots and reduce the risk of them happening again. ELIQUIS can be taken with
or without food, meaning taking it does not need to be timed to a meal. Unlike LOVENOX®, which
is injected, ELIQUIS is taken by mouth twice daily. And unlike warfarin, ELIQUIS has no dietary
restrictions and does not require routine INR blood testing. Find out how ELIQUIS may help.
Other things that may help:
Keep moving—If you’ve been on bed rest because of surgery or other factors, start moving as
soon as your doctor says you’re ready, to help reduce the risk of getting another clot
Stay active on long trips—Long plane or car trips are known to increase the risk of DVT or PE. Move your legs frequently by walking or stretching your legs while sitting
Wear compression stockings—if your doctor recommends, to help reduce the risk of blood
clots in the legs
Follow your doctor's recommendations—Talk to your doctor about certain lifestyle changes to help reduce the risk of DVT and PE, such as maintaining a healthy weight or staying active
*Adapted from: Mayo Clinic. Deep Vein Thrombosis.
Many different factors can raise the risk of developing DVT/PE, including but not limited to:
History of a previous DVT or PE event
Surgery
Broken hip or leg bone, or other trauma
Cancer or some cancer treatments
Pregnancy
Paralysis or long periods of immobilization
Family history and some genetic conditions
Heart disease, such as heart attack or congestive heart failure
Lung disease
Obesity
Taking hormone-based medicines or therapies
Some important safety information to know about ELIQUIS is: (1) Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. For patients taking ELIQUIS for atrial fibrillation: stopping ELIQUIS increases your risk of having a stroke. Talk to your healthcare team before any surgery, medical, or dental procedures. (2) ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop. (3) People who take ELIQUIS and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). (4) A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Get medical help right away if you have sudden chest pain or chest tightness, have sudden swelling of your face or tongue, have trouble breathing, wheezing, or feeling dizzy or faint. This is not a complete list of all important safety information. Please see full Important Safety Information, including Boxed WARNINGS, for ELIQUIS (apixaban). Please see the U.S. Prescribing Information, including Boxed WARNINGS, and the Medication Guide for ELIQUIS (apixaban).
ELIQUIS is a type of blood thinner medicine known as an anticoagulant. Learn more about anticoagulants above.
Your doctor will decide the duration of your treatment. After at least 6 months of treatment for DVT/PE, your doctor may ask you to continue on a lower dose of ELIQUIS to help reduce the risk of them happening again. How long one takes ELIQUIS generally varies from patient to patient. Your doctor will decide the appropriate length of treatment for you.
Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you. For patients taking ELIQUIS: stopping ELIQUIS increases your risk of having a stroke.
Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS your doctor may prescribe another medicine to help prevent a blood clot from forming.
See Important Safety Information below
In patients with deep vein thrombosis (DVT) or pulmonary embolism (PE), ELIQUIS helps prevent blood clots from getting larger as
the body naturally reabsorbs them, and
helps reduce the risk of them happening
again. ELIQUIS selectively blocks one clotting
factor, Factor Xa, and this makes it less likely
that blood clots will form.
View a video to learn more about how ELIQUIS works.
Patients taking ELIQUIS do not need to have routine INR (International Normalized Ratio)
blood testing.
Patients taking ELIQUIS do not have any known dietary restrictions, such as leafy greens.
ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your doctor
will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you
have to stop taking ELIQUIS your doctor may prescribe another medicine to help prevent a blood clot from forming. Be sure to talk to your doctor before any surgeries or procedures, and if you have questions about stopping ELIQUIS before surgery.
Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you. Stopping ELIQUIS increases your risk of having a stroke.
See Important Safety Information below
Determining the price you may pay for a medicine can be complicated and depends on many different factors, such as
insurance coverage. For more information,
view Pricing Information
for ELIQUIS.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is
because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking
ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding
to stop.
You may have a higher risk of bleeding if you take ELIQUIS with other medicines
that increase your risk of bleeding, such as:
Tell your doctor if you take any of these medicines.
Call your doctor or get medical help right away if you have any of these signs or
symptoms of bleeding when taking ELIQUIS:
See Important Safety Information below
Look out for the following
icons as
you read:
Talk to your healthcare team
Call a healthcare provider right away
Helpful information to remember
What are the possible serious side effects of ELIQUIS? This is a list of some of the serious side effects of ELIQUIS.
Bleeding
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:
Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:
Spinal or epidural blood clots (hematoma)
People who take ELIQUIS, and have
medicine injected into their spinal or
epidural area, or have a spinal puncture,
have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).
Your risk of developing a spinal or epidural blood clot is higher if:
If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding.
Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS:
A reaction to ELIQUIS itself
A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS.
Get medical help right away if you have any of the following symptoms:
Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects.
You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.
Who should not take ELIQUIS?
ELIQUIS is not for patients who:
What should I discuss with my healthcare team before starting ELIQUIS?
Talk to your healthcare team about the following:
Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.
Females who are able to become pregnant: talk with your healthcare provider about pregnancy planning, and your risk of severe uterine bleeding if you are treated with blood thinner medicines, including ELIQUIS.
Tell your healthcare team about all the medicines you take, including any:
How should I take ELIQUIS?
Take ELIQUIS exactly as prescribed by your doctor.
Twice daily
With or without food
Do not change your dose or stop taking ELIQUIS unless your doctor tells you to.
What if I miss a dose of ELIQUIS?
If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time.
When should I refill my prescription?
If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not
run out of ELIQUIS. Refill your prescription before
you run out. When leaving the hospital following hip or knee replacement, be sure that
you will have ELIQUIS available to avoid missing any doses.
ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you.
2.5 mg tablet
Round, with a pale yellow color
5 mg tablet
Oval, with a pale orange or pink color
Note: Images do not represent actual tablet size.
On one side of each tablet, there is a number indicating the dosage
strength of the tablet (in milligrams).
On the other side, there is a
medication identification number.
What is ELIQUIS?
ELIQUIS is a prescription medicine used to:
Reduce the risk of stroke and
blood clots in people who have
atrial fibrillation (AFib),
a type of irregular heartbeat,
not
caused by a heart valve
problem.
Treat blood clots in the
veins of the legs (deep vein thrombosis – DVT) or lungs
(pulmonary embolism – PE), and
reduce the risk of them occurring again.
Reduce the risk of forming a
blood clot in the legs (DVT)
and lungs (PE) of people who
have just had hip or knee replacement surgery.
Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.
LOVENOX® is a registered trademark of Aventis Pharma S.A.
The product information provided in this
site is intended only for residents of the
United States. The products discussed herein may have different product labeling in
different countries.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with
a healthcare provider. All decisions
regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who
prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop
taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another
medicine to help prevent a blood clot from forming.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner
medicine that reduces blood clotting.
You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as
aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake
inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots.
Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.
ELIQUIS® and the ELIQUIS logo are trademarks
of Bristol-Myers Squibb Company.
All other trademarks are property of their
respective companies.
© 2022 Bristol-Myers Squibb Company.
432-US-2200454 10/22
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Bristol Myers Squibb
or Pfizer. Bristol Myers Squibb and
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My doctor prescribed ELIQUIS (apixaban) for:
To Reduce Stroke Risk Due to AFib Not Caused by
a Heart Valve Problem
The ELIQUIS® (apixaban)
Starter Kit (PDF)
The ELIQUIS® (apixaban)
Dosing Guide (PDF)
The ELIQUIS® (apixaban)
Discussion Guide (PDF)
The ELIQUIS® (apixaban)
Discussion Guide (PDF)
The ELIQUIS® (apixaban)
Starter Kit (PDF)
Full Prescribing
Information (PDF)
If you need Adobe® Reader®, click the link below to download the free reader
Link to Adobe Reader Download page.
You may be eligible for the Co-pay Card for ELIQUIS® (apixaban) if:
Questions can also be submitted via
mail to:
P.O. Box 2914
Phoenix, AZ, 85062-2914.
BY USING THIS CARD, YOU AND YOUR PHARMACIST UNDERSTAND AND AGREE
TO COMPLY WITH THESE ELIGIBILITY REQUIREMENTS AND TERMS OF USE.
To the pharmacist: For processing assistance, please call McKesson
Pharmacy Support at 1-866-279-4730.
Please see Full Prescribing Information, including Boxed WARNINGS and Medication Guide.
You may be eligible for the Free 30-Day
Trial Offer for ELIQUIS® (apixaban) if:
BY USING THIS CARD, YOU AND YOUR PHARMACIST UNDERSTAND AND
AGREE
TO COMPLY WITH THESE
ELIGIBILITY REQUIREMENTS AND
TERMS OF USE.
To the pharmacist: For processing
assistance, please call McKesson
Pharmacy Support at
Please see Full Prescribing Information, including Boxed WARNINGS and Medication Guide.
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