For People at Risk of Stroke due to AFib Not Caused by a Heart Valve Problem. To Reduce the Risk of Blood Clots After Hip or Knee Replacement Surgery. For People With Deep Vein Thrombosis (DVT) & Pulmonary Embolism (PE). This site is intended for U.S. residents 18 years of age or older.

INDICATIONS

Considering ELIQUIS

In a clinical trial of people with AFib not caused by a heart valve problem, ELIQUIS Was Proven Better Than Warfarin:

Reduced the risk of stroke
better than warfarin

Had significantly less major bleeding* than warfarin

ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death. In another trial compared to aspirin, ELIQUIS has a modest increase in major bleeding.

*Major bleeding included noticeable bleeding with at least 1 of the following—a transfusion of 2 or more units of blood; bleeding that occurred in the brain, spine, eye, around the heart, in a joint, or in a muscle, leading to damage; or fatal bleeding.

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ELIQUIS Was Proven Effective

Based on Extensive Clinical Research

ELIQUIS was studied in 2 clinical trials to evaluate stroke risk reduction in people with AFib not caused by a heart valve problem:

~24,000

PEOPLE PARTICIPATED IN 2 STUDIES

>11,000

PEOPLE TOOK ELIQUIS

Approximately 24,000 people participated in the 2 studies, including more than 11,000 people who took ELIQUIS.

Trial One: Compared ELIQUIS to warfarin in people with AFib not caused by a heart valve problem. This group also had at least one additional risk factor for stroke (a prior stroke, age 75 or older, diabetes, heart failure, high blood pressure).

Trial Two: Compared ELIQUIS to aspirin in people with AFib not caused by a heart valve problem who were not suitable for treatment with warfarin. This group also had at least one additional risk factor for stroke (a prior stroke, age 75 or older, diabetes, heart failure, or peripheral artery disease).

Based on the results of these clinical trials, ELIQUIS was approved to reduce the risk of stroke and blood clots in people with AFib not caused by a heart valve problem.

SELECTED IMPORTANT SAFETY INFORMATION

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.

While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

Please read additional Important Safety Information and ELIQUIS Indications below.


SEE ALSO:
Possible Side Effects


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More Reasons
to Consider ELIQUIS

No routine INR blood testing

With ELIQUIS, there is no routine blood testing, such as the International Normalized Ratio (INR) test, also called INR monitoring.

The INR test checks to see how fast the blood clots while taking warfarin. Warfarin is a medication with a “narrow therapeutic range.” This means that small changes in the medication level may have an impact on the time it takes for blood to clot. Since warfarin has a narrow therapeutic range, the INR test is needed to check a patient’s response to warfarin and to adjust the warfarin dose to keep the INR in the target range.

ELIQUIS does not have a narrow therapeutic range and therefore it is not required for patients taking ELIQUIS to have routine blood testing, such as INR monitoring.

Eat the healthy foods you enjoy

Unlike warfarin, there are no "watch outs" for certain foods like green leafy vegetables when taking ELIQUIS. With ELIQUIS, you can continue eating the healthy foods you like.

Also, ELIQUIS may be taken with or without food. It doesn’t have to be timed to a meal.

No regular dose adjustments

Always take ELIQUIS exactly as prescribed by your doctor.

ELIQUIS comes in either a 5-mg or 2.5-mg tablet. Most people diagnosed with AFib not caused by a heart valve problem will be prescribed 5-mg twice a day.

However, tell your doctor about all medications you take and your medical history, as the lower dose may be appropriate for you. ELIQUIS doesn't require regular dose adjustments.

If you have difficulty swallowing the tablet whole, talk to your doctor about other ways to take ELIQUIS.

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IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.

While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak

ELIQUIS (apixaban) is not for patients with artificial heart valves.

Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:

  • a thin tube called an epidural catheter is placed in your back to give you certain medicine
  • you take NSAIDs or a medicine to prevent blood from clotting
  • you have a history of difficult or repeated epidural or spinal punctures
  • you have a history of problems with your spine or have had surgery on your spine

If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.

Do not take ELIQUIS if you currently have certain types of abnormal bleeding or have had a serious allergic reaction to ELIQUIS.

Before you take ELIQUIS, tell your doctor if you have kidney or liver problems, have any other medical condition, or have ever had bleeding problems. Tell your doctor if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.

Take ELIQUIS exactly as prescribed by your doctor. Take ELIQUIS twice every day with or without food, and do not change your dose or stop taking it unless your doctor tells you to. If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

Possible serious side effects include bleeding or a reaction to ELIQUIS itself. A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Get medical help right away if you have sudden chest pain or chest tightness, have sudden swelling of your face or tongue, have trouble breathing, wheezing, or feeling dizzy or faint.

INDICATIONS

ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation, a type of irregular heartbeat, not caused by a heart valve problem.

ELIQUIS is a prescription medicine used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again.

ELIQUIS is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

LOVENOX® is a registered trademark of Aventis Pharma S.A.

This independent, non-profit organization provides assistance to qualifying patients with financial hardship who generally have no prescription insurance. Contact 1-800-736-0003 or visit www.bmspaf.org for more information.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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SELECTED IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.