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INDICATIONS

About DVT/PE

What you should know about DVT/PE, blood thinners, and prescription ELIQUIS


In the 3 sections below, learn about the connection between DVT and PE, understand the role of blood thinners, and get information about ELIQUIS.

1

Understanding DVT and PE

If you’ve had a DVT or PE, you may
be at risk for having another

EXPLORE MORE ABOUT DVT/PE BLOOD CLOTS BELOW

Deep vein thrombosis (DVT)
& pulmonary embolism (PE)
are serious conditions

A DVT is a blood clot that forms in a deep vein, usually in the thighs or pelvis

The clot, or a part of the clot, may break off and travel through blood vessels toward the lungs

If that blood clot reaches the lungs it is called a PE. A PE can reduce or cut off blood supply to the lungs, and may even cause sudden death

Swelling in the leg or
around a vein in the leg

Pain or tenderness felt when standing
or walking

Redness around the affected area

Difficulty breathing

Faster than normal or irregular heartbeat

Chest pain

Coughing up blood

Very low blood pressure,
light-headedness, or fainting

If you have symptoms of DVT or PE, it is important that you go to your doctor or to the hospital right away. Don’t wait to see if the symptoms will go away—waiting could lead to serious complications. Keep in mind that sometimes people can have a DVT and/or PE and not show any symptoms at all.

Who Is at Risk for Having
Another DVT/PE?

If you’ve had deep vein thrombosis (DVT)
or pulmonary embolism (PE), you may
be at risk of having another case of DVT
or PE. That’s known as a “recurrence.”
Each person’s risk of recurrence varies.

How Common Is Recurrence?

It’s estimated that
1 out of 3 people (33%) with DVT/PE
have a recurrence within 10 years

Other important things to keep in mind:

The risk of recurrence is highest within
the first year
after the initial DVT/PE

In some cases, the risk of recurrence can
remain years after
the first event

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2

The Role of Blood Thinners

Do blood thinners increase
the risk of bleeding?

EXPLORE MORE ABOUT BLOOD THINNERS BELOW

Blood thinners are the
most common treatment for DVT/PE

THEY TREAT DVT/PE BY

Reducing the ability of the blood to clot

Reducing the
risk of further
clots developing

Treatment can help reduce
the risk of recurrence

Taking certain blood thinners can help reduce the risk of recurrence. And that is why, after at least 6 months of a prescription treatment for DVT/PE, your doctor may ask you to continue on ELIQUIS—a blood thinner that is clinically proven to reduce the risk of recurrence of DVT/PE after initial treatment for DVT/PE.


Blood thinners reduce the risk of “bad”
blood clots that can form in a deep vein
(usually in the thighs or pelvis)
and then break off and travel to the lungs.

Blood thinners can also slow
the formation of “good” blood clots, causing unexpected bleeding or preventing clots that form at the site of an injury to stop the bleeding.

Because they help reduce the
risk of blood clots forming,
blood thinners increase the risk of bleeding, which can be serious and rarely may lead to death.

While taking a blood thinner, you may
bruise more easily and it may take longer
than usual for any bleeding to stop.

Be sure to seek medical attention right away if you have signs or symptoms of bleeding such as unexpected bleeding or bleeding that lasts a long time. You may have a higher risk of bleeding if you take blood thinners and take other medicines that increase your risk of bleeding.
Click here for more comprehensive information you should be aware of about bleeding and ELIQUIS.

Your doctor may encourage you to limit
activities that may cause injury and take
some precautions, such as:

Take extra care using knives,
scissors, and nail clippers

Use an electric razor

Wear shoes or non-skid
slippers in the house

Use a soft toothbrush and
waxed dental floss

Wear gloves when using sharp
tools or doing yard work

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3

Know More About ELIQUIS

ELIQUIS treats DVT/PE blood clots and reduces the risk of them
happening again

EXPLORE MORE ABOUT ELIQUIS BELOW

What Is ELIQUIS?

ELIQUIS is a prescription medicine used to
treat blood clots in the veins of your legs
(deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again. Only you and your doctor can decide if ELIQUIS is right for you.

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NEXT: Find out more
about ELIQUIS

Important facts about
ELIQUIS® (apixaban)& INDICATIONS: This is a summary of important information that you need to know about ELIQUIS.

Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you
For patients taking ELIQUIS for atrial fibrillation: stopping ELIQUIS increases your risk of having a stroke.

Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS your doctor may prescribe another medicine to help prevent a blood clot from forming.

  • Look out for the following icons as you read:
  • Talk to your healthcare team
  • Call a healthcare provider right away
  • Helpful information to remember

What are the possible serious side effects of ELIQUIS?
This is a list of some of the serious side effects of ELIQUIS.

Bleeding

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:

  • Aspirin
  • Nonsteroidal anti-inflammatory drugs (called NSAIDs)
  • Warfarin (COUMADIN®)
  • Heparin
  • Selective serotonin reuptake
    inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)
  • Other medicines to help prevent or treat blood clots

Tell your doctor if you take any of these medicines.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • Unexpected bleeding or bleeding that lasts a long time, such as:
    • Unusual bleeding from the gums
    • Nosebleeds that
      happen often
    • Menstrual or vaginal
      bleeding that is heavier than normal
  • Bleeding that is severe or you cannot control
  • Red, pink, or brown urine
  • Red or black stools (looks like tar)
  • Coughing up or vomiting blood
  • Vomit that looks like coffee grounds
  • Unexpected pain, swelling, or joint pain
  • Headaches
  • Feeling dizzy or weak

People who take ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).

Your risk of developing a spinal or epidural blood clot is higher if:

  • A thin tube called an epidural catheter is placed in your back to give you certain medicine
  • You take NSAIDs or a medicine to prevent
    blood
    from clotting
  • You have a history of difficult or repeated epidural or
    spinal punctures
  • You have a history of problems with your spine, or have had surgery on your spine

If you take ELIQUIS and receive spinal anesthesia or a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots
or bleeding.

Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS:

  • Tingling
  • Numbness
  • Muscle weakness

A reaction to ELIQUIS itself

A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS.

Get medical help right away if you have any of the following symptoms:

  • Sudden chest pain or chest tightness
  • Sudden swelling of your face or tongue
  • Trouble breathing
  • Wheezing
  • Feeling dizzy or faint

Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects.

You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.


Who should not take ELIQUIS?

ELIQUIS is not for patients who:

  • have artificial heart valves.
  • have antiphospholipid syndrome (APS).
  • currently have certain types of abnormal bleeding.
  • have had a serious allergic reaction to ELIQUIS.

What should I discuss with my healthcare team before starting ELIQUIS?

Talk to your healthcare team about the following:

  • Kidney or liver problems
  • If you have a condition called antiphospholipid syndrome
  • Any other medical conditions
  • If you have ever had bleeding problems

Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.

Tell your healthcare team about all of the medications you are taking, including:

  • Prescriptions
  • Over-the-counter medicines
  • Herbal supplements
  • Vitamins

During treatment, make sure you talk to your healthcare team before you begin to take any new medication.


How should I take ELIQUIS?

Take ELIQUIS exactly as prescribed by your doctor.

Twice daily
With or without food

Do not change your dose or stop taking ELIQUIS unless your doctor tells you to.

What if I miss a dose of ELIQUIS?

If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time.

When should I refill my prescription?

If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you.

2.5 mg tablet

Round, with a pale yellow color

OR

5 mg tablet

Oval, with a pale orange or pink color

Note: Images do not represent actual tablet size.

On one side of each tablet, there is a number indicating the dosage strength of the tablet (in milligrams). On the other side, there is a medication identification number.


What is ELIQUIS?
ELIQUIS is a prescription medicine used to:

Reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib),
a type of irregular heartbeat, not

caused by a heart valve problem.

Treat blood clots in the veins of the legs (deep vein thrombosis – DVT) or lungs
(pulmonary embolism – PE), and reduce

the risk of them occurring again.

Reduce the risk of forming a blood clot in the legs (DVT) and lungs (PE) of people
who have just had hip or knee replacement surgery.

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

LOVENOX® is a registered trademark of Aventis Pharma S.A.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

432US1802406-03-01 07/19

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SELECTED IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.