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LOVENOX® (enoxaparin) is a blood thinner that is only available in injectable form.

Warfarin is a pill that's taken orally. Patients taking warfarin have to follow certain dietary restrictions. Warfarin also requires patients to go for routine INR blood testing to check if their levels are within the target range and to adjust their warfarin dose if they're not.

DOACs (direct-acting oral anticoagulants), including ELIQUIS, are blood thinners that can help treat DVT and PE clots and reduce the risk of them happening again. ELIQUIS can be taken with or without food, meaning taking it does not need to be timed to a meal. Unlike LOVENOX®, which is injected, ELIQUIS is taken by mouth twice daily. And unlike warfarin, ELIQUIS has no dietary restrictions and does not require routine INR blood testing.

LOVENOX® is a registered trademark of sanofi-aventis U.S. LLC.

Take ELIQUIS exactly as prescribed by your doctor. ELIQUIS is taken by mouth twice daily. The recommended dose of ELIQUIS is 2.5 mg and the initial dose is usually taken 12 to 24 hours after surgery. If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. If you have difficulty swallowing the tablet whole, talk to your doctor about other ways to take ELIQUIS.

Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

Please click here for more information about how to take ELIQUIS.

Your doctor will decide the duration of your treatment. The recommended dose of ELIQUIS is 2.5 mg taken by mouth twice daily. The initial dose is usually taken 12 to 24 hours after surgery.

  • In patients undergoing hip replacement surgery, the recommended duration of treatment is 35 days
  • In patients undergoing knee replacement surgery, the recommended duration of treatment is 12 days

How long ELIQUIS is taken varies from patient to patient. Your doctor will decide the appropriate length of treatment for you.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:

  • Aspirin
  • Nonsteroidal anti-inflammatory drugs (called NSAIDs)
  • Warfarin
  • Heparin
  • Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)
  • Other medicines to help prevent or treat blood clots

Tell your doctor if you take any of these medicines.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • Unexpected bleeding or bleeding that lasts a long time, such as:
    • Unusual bleeding from the gums
    • Nosebleeds that happen often
    • Menstrual or vaginal bleeding that is heavier than normal
  • Bleeding that is severe or you cannot control
  • Red, pink, or brown urine
  • Red or black stools (looks like tar)
  • Coughing up or vomiting blood
  • Vomit that looks like coffee grounds
  • Unexpected pain, swelling, or joint pain
  • Headaches
  • Feeling dizzy or weak

See Important Safety Information below