Indications

  • Adult Nonvalvular AFib

    ELIQUIS (apixaban) is a prescription
    medicine used in adults to reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem.

  • Adult DVT/PE

    ELIQUIS (apixaban) is a prescription
    medicine used in adults to treat blood clots in the veins of your legs (deep vein thrombosis-DVT) or lungs (pulmonary embolism-PE), and to reduce the risk of them occurring again after receiving treatment for blood clots.

  • Pediatric DVT/PE

    ELIQUIS (apixaban) is a prescription
    medicine used in children from birth and older to treat blood clots in the veins of legs and lungs (venous thromboembolism) after at least 5 days of initial anticoagulant treatment, and to reduce the risk of them happening again. ELIQUIS was not studied and is not recommended in children weighing less than 5.7 pounds (2.6 kg).

  • Adult Hip/Knee Replacement

    ELIQUIS (apixaban) is a prescription
    medicine used in adults to help prevent a blood clot in the veins of your legs (deep vein thrombosis-DVT) and lungs (pulmonary embolism-PE) of people who have just had hip or knee replacement surgery.

U.S. Full Prescribing Information Including BOXED WARNINGS

Medication Guide

Healthcare Professionals Site

En Español

Or Call Us at 1-855-ELIQUIS (354-7847)

U.S. Full Prescribing Information Including BOXED WARNINGS

Indications

  • Adult Nonvalvular AFib

    ELIQUIS (apixaban) is a
    prescription medicine used in adults to reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem.

  • Adult DVT/PE

    ELIQUIS (apixaban) is a
    prescription medicine used in adults to treat blood clots in the veins of your legs (deep vein thrombosis-DVT) or lungs (pulmonary embolism-PE), and to reduce the risk of them occurring again after receiving treatment for blood clots.

  • Pediatric DVT/PE

    ELIQUIS (apixaban) is
    a prescription medicine used in children from birth and older to treat blood clots in the veins of legs and lungs (venous thromboembolism) after at least 5 days of initial anticoagulant treatment, and to reduce the risk of them happening again. ELIQUIS was not studied and is not recommended in children weighing less than 5.7 pounds (2.6 kg).

  • Adult Hip/Knee Replacement

    ELIQUIS (apixaban) is a
    prescription medicine used in adults to help prevent a blood clot in the veins of your legs (deep vein thrombosis-DVT) and lungs (pulmonary embolism-PE) of people who have just had hip or knee replacement surgery.

Medication Guide

Or Call Us at 1-855-ELIQUIS (354-7847)

DVT/PE Home

About DVT/PE

Talking With Your Doctor

Frequently Asked Questions

Healthcare Professionals Site

En Español

This site is intended for U.S. residents 18 years of age or older.

Frequently Asked Questions

Deep vein thrombosis (DVT) is a blood clot that occurs most commonly in the leg, thigh, or pelvis, but may also occur in the arm. If a DVT blood clot breaks free, it can travel to the lungs, which is known as a pulmonary embolism (PE). A PE can limit the flow of blood in the lungs and can even cause death. Patients who have had a DVT or PE are at risk for them happening again.

Both DVT and PE are fairly common. In 2010, it was estimated that each year there are as many as 900,000 adults in the U.S. with DVT/PE. About one third of DVT/PE events are PE.

DVT and PE are a public health concern:

  • PE can cause sudden death in about 25% of cases
  • Up to 100,000 adult patients in the U.S. are estimated to die due to DVT/PE each year

Pulmonary embolism (PE): The most serious risk from DVT is PE. A PE clot can limit the flow of blood in the lungs and can even cause sudden death.

DVT and/or PE can happen more than once. About 33% of patients with DVT or PE have another case, or recurrence, within 10 years of their first DVT or PE.

Doctors may use multiple tests to find out if you have DVT or PE.

Usually, a diagnosis of DVT and/or PE is based upon:

Medical history: Includes questions about your overall health and any prescription medicines you’re taking.

Physical exam: A healthcare provider will examine your legs for signs of DVT and evaluate your blood pressure, your heart, and your lungs.

Test results: Certain tests can help diagnose DVT and PE. Some of the common ones include:

  • Ultrasound: Doctors can use ultrasound to look for blood clots in your legs and pelvis. Ultrasound uses sound waves to check blood flow in your veins
  • CT scans: The test uses X-rays and allows doctors to detect most cases of PE
  • D-dimer test: A blood test that measures a substance in the blood that’s released when a blood clot dissolves

The most common DVT treatments and PE treatments are anticoagulants, otherwise known as blood thinners. Blood thinners treat deep vein thrombosis (DVT) and pulmonary embolism (PE) by reducing the ability of the blood to clot and reducing the risk of further clots developing.

Here are some commonly prescribed blood thinners for DVT/PE and some of the differences between them. You can also learn about the clinical studies that compared ELIQUIS with LOVENOX® (enoxaparin) followed by warfarin.

LOVENOX® (enoxaparin) is a blood thinner that is only available in injectable form.

Warfarin is a pill that’s taken orally. Patients taking warfarin have to follow certain dietary restrictions. Warfarin also requires patients to go for routine INR blood testing to check if their levels are within the target range and to adjust their warfarin dose if they’re not.

DOACs (direct-acting oral anticoagulants), including ELIQUIS, are blood thinners that can help treat DVT and PE clots and reduce the risk of them happening again after receiving treatment for blood clots. Unlike LOVENOX®, which is injected, ELIQUIS is taken by mouth twice daily. And unlike warfarin, ELIQUIS has no dietary restrictions and does not require routine INR blood testing. Find out how ELIQUIS may help.

LOVENOX® is a registered trademark of sanofi-aventis U.S. LLC.

Other things that may help:

Keep moving—If you’ve been on bed rest because of surgery or other factors, start moving as soon as your doctor says you’re ready, to help reduce the risk of getting another clot

Stay active on long trips—Long plane or car trips are known to increase the risk of DVT or PE. Move your legs frequently by walking or stretching your legs while sitting

Wear compression stockings—If your doctor recommends, to help reduce the risk of blood clots in the legs

Follow your doctor's recommendations—Talk to your doctor about certain lifestyle changes to help reduce the risk of DVT and PE, such as maintaining a healthy weight or staying active

*Adapted from: Mayo Clinic. Deep Vein Thrombosis.

Many different factors can raise the risk of developing DVT/PE, including but not limited to:

  • History of a previous DVT or PE event
  • Surgery
  • Broken hip or leg bone, or other trauma
  • Cancer or some cancer treatments
  • Pregnancy
  • Paralysis or long periods of immobilization
  • Family history and some genetic conditions
  • Heart disease, such as heart attack or congestive heart failure
  • Lung disease
  • Obesity
  • Taking hormone-based medicines or therapies

ELIQUIS may cause serious side effects, including: (1) Increased risk of blood clots if you stop taking ELIQUIS. ELIQUIS lowers your chance of having a stroke by helping to prevent clots from forming. Do not stop taking ELIQUIS without talking to the healthcare provider who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke. ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your healthcare provider will tell you when you should stop taking ELIQUIS and when you may start taking it again. (2) ELIQUIS can cause bleeding, which can be serious, and may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop. (3) People who take ELIQUIS and have medicine injected into their spinal and epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). (4) Do not take ELIQUIS if you currently have certain types of abnormal bleeding or have had a severe allergic reaction to ELIQUIS or any of the ingredients. This is not a complete list of all important safety information. Please see full Important Safety Information. Please see the U.S. Prescribing Information, including Boxed WARNINGS, and the Medication Guide for ELIQUIS (apixaban).

ELIQUIS is a type of blood thinner medicine known as an anticoagulant. Learn more about anticoagulants here.

Your healthcare provider will decide the duration of your treatment. After at least 6 months of treatment for DVT/PE, your healthcare provider may ask you to continue on a lower dose of ELIQUIS to help reduce the risk of them happening again. How long one takes ELIQUIS generally varies from patient to patient. Your healthcare provider will decide the appropriate length of treatment for you.

Do not stop taking ELIQUIS without talking to the healthcare provider who prescribed it to you. Stopping ELIQUIS increases the risk of blood clots, including stroke and DVT/PE.

Talk to your healthcare provider before any medical procedures. ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your healthcare provider will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS your healthcare provider may prescribe another medicine to help prevent a blood clot from forming.

See Important Safety Information below.

In patients with deep vein thrombosis (DVT) or pulmonary embolism (PE), ELIQUIS helps prevent blood clots from getting larger as the body naturally reabsorbs them, and helps reduce the risk of them happening again. ELIQUIS selectively blocks one clotting factor, Factor Xa, and this makes it less likely that blood clots will form.

View a video to learn more about how ELIQUIS works.

Patients taking ELIQUIS do not need to have routine INR (International Normalized Ratio) blood testing.

Patients taking ELIQUIS do not have any known dietary restrictions, such as leafy greens.

ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your healthcare provider will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS your healthcare provider may prescribe another medicine to help prevent a blood clot from forming. Be sure to talk to your healthcare provider before any surgeries or procedures, and if you have questions about stopping ELIQUIS before surgery.

Do not stop taking ELIQUIS without talking to the healthcare provider who prescribed it to you. Stopping ELIQUIS increases the risk of blood clots, including stroke and DVT/PE.

See Important Safety Information below.

Determining the price you may pay for a medicine can be complicated and depends on many different factors, such as insurance coverage. For more information, view Pricing Information for ELIQUIS.

ELIQUIS can cause bleeding, which can be serious, and may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, including:

  • Aspirin
  • Nonsteroidal anti-inflammatory drugs (called NSAIDs)
  • Warfarin
  • Heparin
  • Clopidogrel
  • Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)
  • Other medicines to help prevent or treat blood clots

Tell your healthcare provider if you take any of these medicines.

Call your healthcare provider or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • Unexpected bleeding or bruising, or bleeding that lasts a long time, such as:
    • Unusual bleeding from the gums
    • Nose bleeds that happen often
    • Menstrual or vaginal bleeding that is heavier than normal
  • Bleeding that is severe or you cannot control
  • Red, pink, or brown urine; red or black stools (looks like tar)
  • Cough up blood or blood clots
  • Vomit blood or your vomit looks like “coffee grounds”
  • Unexpected pain, swelling, or joint pain
  • Headaches, feeling dizzy or weak

See Important Safety Information below.

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Important facts about ELIQUIS® (apixaban) tablets and ELIQUIS® SPRINKLE (apixaban)

This is a summary of important safety information that you need to know about ELIQUIS. Keep this document in a safe place, so you can refer to it before and during your treatment.

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Helpful information
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What is the most important information I should know about ELIQUIS?

ELIQUIS may cause serious side effects, including:

Increased risk of blood clots if you stop taking ELIQUIS

ELIQUIS lowers your chance of having a stroke by helping to prevent clots from forming. If you stop taking ELIQUIS, you may have an increased risk of a clot forming in your blood.

Do not stop taking ELIQUIS without talking to the healthcare provider who prescribed it to you.

Stopping ELIQUIS increases your risk of having a stroke.

Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery or a medical or dental procedure. Your healthcare provider will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your healthcare provider may prescribe another medicine to help prevent a blood clot from forming.

Bleeding

ELIQUIS can cause bleeding, which can be serious, and may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as:

  • Aspirin or aspirin-containing products

  • Long-term (chronic) nonsteroidal anti-inflammatory drugs (called NSAIDs)

  • Warfarin sodium

  • Any medicine that contains heparin

  • Clopidogrel

  • Selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)

  • Other medicines to help prevent or treat blood clots

Tell your healthcare provider if you take any of these medicines.

Call your healthcare provider or get medical help right away if you or your child have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • Unexpected bleeding or bruising or bleeding that lasts a long time, such as:

    • Unusual bleeding from the gums

    • Nosebleeds that happen often

    • Menstrual or vaginal bleeding that is heavier than normal

  • Bleeding that is severe or you cannot control

  • Red, pink, or brown urine

  • Red or black stools (looks like tar)

  • Coughing up or vomiting blood or blood clots

  • Vomit that looks like coffee grounds

  • Unexpected pain, swelling, or joint pain

  • Headaches

  • Feeling dizzy or weak

Spinal or epidural blood clots (hematoma)

People who take a blood thinner medicine like ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).

Your risk of developing a spinal or epidural blood clot is higher if:

  • A thin tube called an epidural catheter is placed in your back to give you certain medicine

  • You take NSAIDs or a medicine to prevent blood from clotting

  • You have a history of difficult or repeated epidural or spinal punctures

  • You have a history of problems with your spine or have had surgery on your spine

If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your healthcare provider should watch you closely for symptoms of spinal or epidural blood clots or bleeding.

Tell your healthcare provider right away if you have any of these signs or symptoms when taking ELIQUIS:

  • Back pain

  • Tingling, numbness, or muscle weakness, especially in your legs and feet

  • Loss of control of the bowels or bladder (incontinence)

Talk to your healthcare provider about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your healthcare provider for medical advice about side effects.

You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.

Who should not take ELIQUIS?

ELIQUIS is not for patients who:

  • have artificial heart valves

  • have antiphospholipid syndrome (APS), especially with positive triple antibody testing

  • currently have certain types of abnormal bleeding

  • have had a serious allergic reaction to ELIQUIS or any of the ingredients

What should I discuss with my healthcare team before starting ELIQUIS?

Talk to your healthcare team if you or your child:

  • Have or ever had bleeding problems

  • Have kidney or liver problems

  • Have antiphospholipid syndrome (APS)

  • Are pregnant or plan to become pregnant. It is not known if ELIQUIS will harm your unborn baby

Tell your healthcare provider right away if you become pregnant during treatment with ELIQUIS. Taking ELIQUIS during pregancy may increase the risk of bleeding in you or your unborn baby.

Females who are able to become pregnant: talk with your healthcare provider about pregnancy planning, and your risk of severe uterine bleeding if you are treated with ELIQUIS.

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if ELIQUIS passes into your breast milk. Do not breastfeed during treatment with ELIQUIS. Talk to your healthcare provider about the best way to feed your baby during treatment with ELIQUIS.

Tell your healthcare team about all the medicines you or your child take, including any:

  • prescription medicines

  • over-the-counter medicines

  • vitamins

  • herbal supplements

During treatment, make sure you talk to your healthcare team before you begin to take any new medication.

What are the possible serious side effects of ELIQUIS?

The most common side effect of ELIQUIS in adults was bleeding.

The most common side effects of ELIQUIS in children include: headache, vomiting, heavy menstrual bleeding.

How should I take ELIQUIS?

Take ELIQUIS exactly as prescribed by your healthcare provider.

  • Twice daily

Do not change your dose or stop taking ELIQUIS unless your healthcare provider tells you to.

What if I miss a dose of ELIQUIS?

If you or your child misses a dose of ELIQUIS, take it as soon as you remember on the same day. Do not take two doses of ELIQUIS at the same time to make up for a missed dose. Return to your usual dosing schedule the next day.

For children who take ELIQUIS:

  • See the detailed Instructions for Use that comes with ELIQUIS SPRINKLE for oral suspension or ELIQUIS tablets for oral suspension for information on how to prepare and give a dose of ELIQUIS to children who weigh less than 77 pounds (35 kg).

  • Always give ELIQUIS exactly as your child’s healthcare provider or pharmacist has told you.

  • The dose of ELIQUIS is based on your child’s body weight. Your child’s healthcare provider may need to change your child’s dose as their weight changes. Do not change your child’s dose without talking with the healthcare provider.

  • If your child vomits or spits up within 30 minutes after taking ELIQUIS, repeat the dose. If your child vomits or spits up more than 30 minutes after taking ELIQUIS, do not repeat the dose. Continue to give the next ELIQUIS dose at the next scheduled time.

  • Contact the healthcare provider if your child repeatedly vomits or spits up after taking ELIQUIS.

When should I refill my prescription?

Do not stop taking ELIQUIS without first talking with your healthcare provider. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

ELIQUIS is available in two different tablets. Your healthcare provider will determine what dose is right for you.

2.5 mg tablet

Yellow, round

OR

5 mg tablet

Pink, oval

On one side of each film-coated tablet, there is a number indicating the dosage strength of the tablet (in milligrams). On the other side, there is a medication identification number.

ELIQUIS is also available as ELIQUIS SPRINKLE, a capsule containing a powder for oral suspension, or as a film-coated tablet for oral suspension for pediatric patients.

0.15 mg capsule

Yellow, opaque

OR

0.5 mg tablet

Pink, round

Note: Images do not represent actual tablet or capsule size.

The capsule is printed with a medication identification number.

What is ELIQUIS?

ELIQUIS is a prescription medicine used in adults to:

Reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem.

Treat blood clots in the veins of the legs (deep vein thrombosis – DVT) or lungs (pulmonary embolism – PE), and reduce the risk of them occurring again after receiving treatment for blood clots.

Help prevent a blood clot in the legs (DVT) and lungs (PE) of people who have just had hip or knee replacement surgery.

ELIQUIS is a prescription medicine used in children from birth and older to:

Treat blood clots in the veins of the legs and lungs (venous thromboembolism) after at least 5 days of initial coagulant treatment, and reduce the risk of them occurring again.

ELIQUIS was not studied and is not recommended in children who weigh less than 5.7 pounds (2.6 kg).

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

432-US-2500142 07/25