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DVT is a blood clot in a deep vein—usually in the thighs or pelvis—that limits the flow of blood in veins. Sometimes a DVT blood clot can break free and travel to the lungs. This is known as a PE. A PE blood clot can limit the flow of blood in the lungs and can even cause sudden death. DVT and PE can happen more than once.
Dr. Why Explains DVT and PE
Both DVT and PE are fairly common. It’s estimated that each year there are close to 1 million adults in the U.S. with DVT and/or PE. About one third of DVT/PE events are PE.
PE can cause sudden death
in about 25% of cases
Up to 100,000 people
in the U.S. are estimated
to die due to DVT/PE
Within 1 month
of diagnosis, 10% – 30% of people
die due to DVT/PE
Pulmonary embolism (PE): The most serious risk from DVT is PE. A PE clot can limit the flow of blood in the lungs and can even cause sudden death.
DVT and/or PE can happen more than once. About 33% of people with DVT or PE have a recurrence within 10 years of their first DVT or PE.
The most common treatment for DVT/PE is anticoagulants, otherwise known as blood thinners. Blood thinners treat deep vein thrombosis (DVT) and pulmonary embolism (PE) by reducing the ability of the blood to clot and reducing the risk of further clots developing.
Doctors may use multiple tests to find out if you have DVT or PE.
Includes questions about your overall health and any prescription medicines you’re taking.
A doctor will examine your legs for signs of DVT and evaluate your blood pressure, your heart, and your lungs.
Certain tests can help diagnose DVT and PE. Some of the common ones include:
LOVENOX® (enoxaparin) is a blood thinner that is only available in injectable form.
Warfarin is a pill that’s taken orally. Patients taking warfarin have to follow certain dietary restrictions. Warfarin also requires patients to go for routine INR blood testing to check if their levels are within the target range and to adjust their warfarin dose if they’re not.
ELIQUIS is another blood thinner that can help treat DVT and PE clots and reduce the risk of them happening again. ELIQUIS can be taken with or without food, meaning taking it does not need to be timed to a meal. Unlike LOVENOX®, which is injected, ELIQUIS is taken by mouth twice daily. And unlike warfarin, ELIQUIS has no dietary restrictions and does not require routine INR blood testing. Find out how ELIQUIS may help.
Other things that may help:
*Adapted from: Mayo Clinic. Deep Vein Thrombosis.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death.
You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding. Tell your doctor about all of the medicines you take.
While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
Call your doctor or get medical help right away if you have any signs or symptoms of bleeding when taking ELIQUIS.
Please click here for signs and symptoms of bleeding.
Your doctor will decide the duration of your treatment. After at least 6 months of treatment for DVT/PE, your doctor may ask you to continue on a lower dose of ELIQUIS to help reduce the risk of them happening again. How long one takes ELIQUIS generally varies from patient to patient. Your doctor will decide the appropriate length of treatment for you.
Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you
For patients taking ELIQUIS for atrial fibrillation: stopping ELIQUIS increases your risk of having a stroke.
Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS your doctor may prescribe another medicine to help prevent a blood clot from forming.
What are the possible serious side effects of ELIQUIS?
This is a list of some of the serious side effects of ELIQUIS.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:
Tell your doctor if you take any of these medicines.
Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:
People who take ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).
Your risk of developing a spinal or epidural blood clot is higher if:
If you take ELIQUIS and receive spinal anesthesia or a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots
Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS:
A reaction to ELIQUIS itself
A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS.
Get medical help right away if you have any of the following symptoms:
Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects.
You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.
Who should not take ELIQUIS?
ELIQUIS is not for patients who:
What should I discuss with my healthcare team before starting ELIQUIS?
Talk to your healthcare team about the following:
Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.
Tell your healthcare team about all of the medications you are taking, including:
During treatment, make sure you talk to your healthcare team before you begin to take any new medication.
How should I take ELIQUIS?
Take ELIQUIS exactly as prescribed by your doctor.
Do not change your dose or stop taking ELIQUIS unless your doctor tells you to.
What if I miss a dose of ELIQUIS?
If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time.
When should I refill my prescription?
If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.
ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you.
2.5 mg tablet
Round, with a pale yellow color
5 mg tablet
Oval, with a pale orange or pink color
Note: Images do not represent actual tablet size.
On one side of each tablet,there is a number indicating the dosage strength of the tablet (in milligrams). On the other side, there is a medication identification number.
What is ELIQUIS?
ELIQUIS is a prescription medicine used to:
Reduce the risk of stroke and
a type of irregular heartbeat, not
caused by a heart valve problem.
Treat blood clots in the veins
(pulmonary embolism – PE), and reduce
the risk of them occurring again.
Reduce the risk of forming a blood clot in the legs (DVT) and lungs (PE) of people
who have just had hip or knee replacement surgery.
LOVENOX® is a registered trademark of Aventis Pharma S.A.
The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.
You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.