For people at risk of stroke due to AFib Not Caused by a Heart Valve Problem. To Reduce the Risk of Blood Clots After Hip or Knee Replacement Surgery. For People With Deep Vein Thrombosis (DVT) & Pulmonary Embolism (PE). This site is intended for U.S. residents 18 years of age or older.

INDICATIONS

AFib & Stroke Risk
What Is Nonvalvular AFib?

There are 2 types of AFib: one that is caused by a heart valve problem, and one that is not. Most cases of AFib are not caused by a heart valve problem. AFib not caused by a heart valve problem means the same thing as “nonvalvular atrial fibrillation,” or NVAF, which is estimated to affect approximately 6.4 million people in the U.S. in 2014.


SEE ALSO:
What Are Some Symptoms of AFib?


What Is Happening In My Heart?

Try to picture your heart as a soft squeeze bottle filled with liquid.

Now imagine pressing very quickly but lightly. You never get all the liquid out the way you would with a full squeeze.

Similarly in the heart, this can allow blood to pool in the atria.

If you have atrial fibrillation (AFib), the top 2 chambers of your heart, the atria, quiver (fibrillate) instead of contracting with a full squeeze. Because of this, the atria do not push all the blood out to where it should go, the ventricles.

The blood left in the atria can pool and clump together, increasing the risk for clots to form. If a clot breaks loose and travels to the brain, blocking or limiting blood flow, it can cause a stroke.

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What Are Some Risks With AFib?

GREATER RISK OF STROKE

People who have AFib not caused by a heart valve problem are at 5 times greater risk of suffering a stroke. So it’s important to ask your doctor about treatment options that can help reduce the risk of stroke.

Watch this animation for a better understanding of the steps that may lead to a stroke:

HOW A CLOT IN THE HEART MAY LEAD TO A STROKE IN THE BRAIN

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What Are Some Signs and
Symptoms of a Stroke?

Learn the signs of a stroke—and act fast

If you or someone you know has AFib, make sure you know the signs of stroke really well—knowing these can help you act fast and get immediate medical attention.

Remember, stroke is a medical emergency. If you notice any of the signs listed below, call 9-1-1 immediately.
Sudden numbness or weakness of the face, arm, or leg, especially on one side of the body
Sudden droopiness in the mouth while trying to smile
Sudden change around vision: blurred, blackened, or double vision in one or both eyes
Sudden headache with or without vomiting and dizziness
Sudden loss of balance or coordination
Sudden trouble with speaking or understanding speech

Note the time when the signs first begin. This information is important for your doctor to know.

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What Blood Thinner Options Are Available?

When you learn that you have AFib not caused by a heart valve problem, your next question may be: so what can I do to help decrease the risk of stroke? Fortunately there are treatments available. Doctors often prescribe blood thinners to reduce the risk of blood clots and stroke due to AFib not caused by a heart valve problem.

Choosing a Blood Thinner with your doctor

For over 60 years, people with AFib were prescribed a blood thinner called warfarin. These days you have more choices. Working with your doctor is the first step in finding out if stroke risk reduction treatment with ELIQUIS is a better option for you than warfarin.

Questions for Your Doctor can help you get the answers you need.


SEE ALSO:
How ELIQUIS May Help


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IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.

While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak

ELIQUIS (apixaban) is not for patients with artificial heart valves.

Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:

  • a thin tube called an epidural catheter is placed in your back to give you certain medicine
  • you take NSAIDs or a medicine to prevent blood from clotting
  • you have a history of difficult or repeated epidural or spinal punctures
  • you have a history of problems with your spine or have had surgery on your spine

If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.

Do not take ELIQUIS if you currently have certain types of abnormal bleeding or have had a serious allergic reaction to ELIQUIS.

Before you take ELIQUIS, tell your doctor if you have kidney or liver problems, have any other medical condition, or have ever had bleeding problems. Tell your doctor if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.

Take ELIQUIS exactly as prescribed by your doctor. Take ELIQUIS twice every day with or without food, and do not change your dose or stop taking it unless your doctor tells you to. If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

Possible serious side effects include bleeding or a reaction to ELIQUIS itself. A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Get medical help right away if you have sudden chest pain or chest tightness, have sudden swelling of your face or tongue, have trouble breathing, wheezing, or feeling dizzy or faint.

INDICATIONS

ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation, a type of irregular heartbeat, not caused by a heart valve problem.

ELIQUIS is a prescription medicine used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again.

ELIQUIS is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

LOVENOX® is a registered trademark of Aventis Pharma S.A.

This independent, non-profit organization provides assistance to qualifying patients with financial hardship who generally have no prescription insurance. Contact 1-800-736-0003 or visit www.bmspaf.org for more information.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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SELECTED IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.