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INDICATIONS

AFib & Stroke Risk

What you should know about AFib
& stroke risk, blood thinners,
and prescription ELIQUIS

In the 3 sections below, learn how AFib not caused by a heart valve problem can lead to a stroke, understand the role of blood thinners, and get information about ELIQUIS.

When I first received
my AFib diagnosis, I was
devastated, so I educated myself
more about what AFib was

Myra, a real ELIQUIS patient

She was compensated for her
time and expenses.

I talked to my doctor
so I could understand why
he prescribed ELIQUIS

Joe, a real ELIQUIS patient

He was compensated for his
time and expenses.

My doctor talked to me about
the risk of stroke, and we decided
ELIQUIS was right for me

Ken, a real ELIQUIS patient

He was compensated for his
time and expenses.

1

The Link Between AFib & Stroke

If you have AFib not caused by a
heart valve problem, you are
5x more likely to have a stroke

Explore more about stroke risk below

The most common type of
atrial fibrillation (AFib) is
not caused by a heart valve
problem. It is also known as
“nonvalvular AFib” or NVAF.

It was estimated that in 2020

~8.5 million
people in the U.S.

would have AFib not caused by a heart valve problem. The exact cause of AFib is not always known, but the risk increases as you get older.

What Is Happening
in my Heart?

Try to picture your heart as a soft squeeze bottle filled with liquid.

Now imagine pressing very quickly but lightly. You never get all the liquid out the way you would with a full squeeze.

Similarly, in the heart, this can allow blood to pool in the atria, the top chambers of the heart.

Healthy Heartbeat [Audio 0:45]

AFib Not Caused by a Heart Valve Problem Heartbeat [Audio 0:43]

Some common symptoms
of AFib not caused by a
heart valve problem:

Heart palpitations

Shortness of breath

Dizziness or fatigue

Chest pain

IMPORTANT: The symptoms can be different for everyone. Some people don’t feel any symptoms at all.

How can AFib lead to
a stroke in the brain?

In a healthy heart, the upper chambers (atria) pump blood to the lower chambers (ventricles) and to the rest of the body

With AFib, the atria quiver instead of pumping with a steady beat. This may cause blood to pool in the atria, which can lead to blood clots forming

If a blood clot, or piece of it, breaks off, it can travel out of the heart, through the blood vessels, and to the brain—where it
can cause a stroke

REMEMBER: Since people with AFib not caused by a heart valve problem are at a higher risk of stroke, it’s important to ask your doctor about treatment options that can help reduce the risk of stroke.

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2

The Role of Blood Thinners

Do blood thinners increase
the risk of bleeding?

EXPLORE MORE ABOUT BLOOD THINNERS BELOW

Blood thinners are
commonly prescribed for
people with AFib not caused
by a heart valve problem

BLOOD THINNERS WORK TO

Help reduce the risk of blood clots forming in the atria

And therefore reduce the risk of stroke due to blood clots in the atria traveling to the brain

Choosing a blood thinner
with your doctor

For more than 60 years, people with AFib were prescribed a blood thinner called warfarin. These days, you have more choices. Working with your doctor is the first step in finding out if stroke risk reduction treatment with ELIQUIS may be the right option for you.

Blood thinners reduce the risk
of “bad” blood clots that can
form in the heart and then break
off and travel to the brain.

Blood thinners can also slow the
formation of “good” blood clots,
causing unexpected bleeding or
preventing clots that form at the site
of an injury to stop the bleeding.

Because they help reduce the
risk of blood clots forming,
blood thinners increase the risk of bleeding, which can be serious and rarely may lead to death.

While taking a blood thinner, you may
bruise more easily and it may take longer
than usual for any bleeding to stop.

Be sure to seek medical attention right away if you have signs or symptoms of bleeding such as unexpected bleeding or bleeding that lasts a long time. You may have a higher risk of bleeding if you take blood thinners and take other medicines that increase your risk
of bleeding.
Click here for more comprehensive information you should be aware of about bleeding and ELIQUIS.

Your doctor may encourage you to limit
activities that may cause injury and take
some precautions, such as:

Take extra care using knives,
scissors, and nail clippers

Use an electric razor

Wear shoes or non-skid
slippers in the house

Use a soft toothbrush and
waxed dental floss

Wear gloves when using sharp
tools or doing yard work

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3

Know More About ELIQUIS

ELIQUIS reduces the risk of stroke for people with AFib not caused by a heart valve problem

EXPLORE MORE ABOUT ELIQUIS BELOW

What Is ELIQUIS?

ELIQUIS is a prescription blood thinner
used to reduce the risk of stroke
and blood clots in people who have
atrial fibrillation (AFib), a type of
irregular heartbeat, not caused by
a heart valve problem. Only you and
your doctor can decide if ELIQUIS
is right for you.

In a clinical trial
of people with
AFib not caused by a
heart valve problem

ELIQUIS was proven
to reduce
stroke risk
better than warfarin

Plus, ELIQUIS has
significantly less
major bleeding*
than warfarin

ELIQUIS has both

In a clinical trial of people with AFib
not caused by a heart valve problem

ELIQUIS Was Proven Better
Than Warfarin:

Reduces stroke risk
better than warfarin

Significantly less major
bleeding* than warfarin

ELIQUIS and other blood thinners increase
the risk of bleeding, which can be serious,
and rarely may lead to death. In another trial,
compared to aspirin, ELIQUIS had a modest
increase in major bleeding.

*Major bleeding included noticeable bleeding with at
least 1 of the following—a transfusion of 2 or more units
of blood; bleeding that occurred in the brain, spine, eye,
inside the abdomen, around the heart, in a joint,
or in a muscle, leading to damage; or fatal bleeding.

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NEXT: Find out more
about ELIQUIS
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Important facts about
ELIQUIS® (apixaban)& INDICATIONS: This is a summary of important information that you need to know about ELIQUIS.

Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you
For patients taking ELIQUIS for atrial fibrillation: stopping ELIQUIS increases your risk of having a stroke.

Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS your doctor may prescribe another medicine to help prevent a blood clot from forming.

  • Look out for the following icons as you read:
  • Talk to your healthcare team
  • Call a healthcare provider right away
  • Helpful information to remember

What are the possible serious side effects of ELIQUIS?
This is a list of some of the serious side effects of ELIQUIS.

Bleeding

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:

  • Aspirin
  • Nonsteroidal anti-inflammatory drugs (called NSAIDs)
  • Warfarin (COUMADIN®)
  • Heparin
  • Selective serotonin reuptake
    inhibitors (SSRIs) or serotonin
    norepinephrine reuptake inhibitors (SNRIs)
  • Other medicines to help prevent or treat blood clots

Tell your doctor if you take any of these medicines.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • Unexpected bleeding or bleeding that lasts a long time, such as:
    • Unusual bleeding from the gums
    • Nosebleeds that
      happen often
    • Menstrual or vaginal
      bleeding that is heavier than normal
  • Bleeding that is severe or you cannot control
  • Red, pink, or brown urine
  • Red or black stools (looks like tar)
  • Coughing up or vomiting blood
  • Vomit that looks like coffee grounds
  • Unexpected pain, swelling, or joint pain
  • Headaches
  • Feeling dizzy or weak

People who take ELIQUIS, and have medicine injected into their spinal or epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).

Your risk of developing a spinal or epidural blood clot is higher if:

  • A thin tube called an epidural catheter is placed in your back to
  • You take NSAIDs or a from clotting
  • You have a history of difficult or repeated epidural or
    spinal punctures
  • You have a history of problems with your spine, or have had surgery on your spine

If you take ELIQUIS and receive spinal anesthesia or a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots
or bleeding.

Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS:

  • Tingling
  • Numbness
  • Muscle weakness

A reaction to ELIQUIS itself

A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS.

Get medical help right away if you have any of the following symptoms:

  • Sudden chest pain or chest tightness
  • Sudden swelling of your face or
    tongue
  • Trouble breathing
  • Wheezing
  • Feeling dizzy or faint

Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects.

You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.

Who should not take ELIQUIS?

ELIQUIS is not for patients who:

  • have artificial heart valves.
  • have antiphospholipid syndrome (APS), especially with positive triple antibody testing, who have a history of blood clots.
  • currently have certain types of abnormal bleeding.
  • have had a serious allergic reaction to ELIQUIS.

What should I discuss with my healthcare team before starting ELIQUIS?

Talk to your healthcare team about the following:

  • Kidney or liver problems
  • If you have antiphospholipid syndrome
  • Any other medical conditions
  • If you have ever had bleeding problems

Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.

Tell your healthcare team about all of the medications you are taking, including:

  • Prescriptions
  • Over-the-counter medicines
  • Herbal supplements
  • Vitamins

During treatment, make sure you talk to your healthcare team before you begin to take any new medication.

How should I take ELIQUIS?

Take ELIQUIS exactly as prescribed by your doctor.

Twice daily
With or without food

Do not change your dose or stop taking ELIQUIS unless your doctor tells you to.

What if I miss a dose of ELIQUIS?

If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time.

When should I refill my prescription?

If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you.

2.5 mg tablet

Round, with a pale yellow color

OR

5 mg tablet

Oval, with a pale orange or pink color

Note: Images do not represent actual tablet size.

On one side of each tablet, there is a number indicating the dosage strength of the tablet (in milligrams). On the other side, there is a medication identification number.

What is ELIQUIS?
ELIQUIS is a prescription medicine used to:

Reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib),
a type of irregular heartbeat, not

caused by a heart valve problem.

Treat blood clots in the veins of the legs (deep vein thrombosis – DVT) or lungs
(pulmonary embolism – PE), and reduce

the risk of them occurring again.

Reduce the risk of forming a blood clot in the legs (DVT) and lungs (PE) of people
who have just had hip or knee replacement surgery.

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

LOVENOX® is a registered trademark of Aventis Pharma S.A.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call

432US1903243-03-01 07/20

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SELECTED IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.

AFib Not Caused by
a Heart Valve Problem

DVT/PE

Hip or Knee
Replacement Surgery

ELIQUIS® and the ELIQUIS logo are trademarks of Bristol-Myers Squibb Company.

COUMADIN® is a registered trademark of Bristol-Myers Squibb Pharma Company.
All other trademarks are property of their 
respective companies.

© 2020 Bristol-Myers Squibb Company. 432US1903243-01-01  01/20