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In the 3 sections below, learn how AFib not caused by a heart valve problem can lead
a stroke, understand the role of blood
thinners, and get information about ELIQUIS.
Did you know?
Patients with AFib not caused by a heart valve problem are ≈5x more likely to have a stroke
Explore more about stroke risk below
The most common type of atrial fibrillation (AFib) is not caused by a
heart valve problem. It is also known as nonvalvular AFib, or NVAF.
It was estimated that in 2021 ~8.7 million patients in the U.S. would have
AFib not caused by a heart valve problem. The exact cause of AFib is not
always known, but the risk increases as you get older.
Try to picture your heart as a soft squeeze bottle filled with liquid.
Now imagine pressing very quickly but lightly. You never get all the liquid out the way you would with a full squeeze.
Similarly, in the heart, this can allow blood to pool in the atria, the
top chambers of the heart.
The symptoms can be different
for everyone. Some patients don't
any symptoms at all.
In a healthy heart, the upper chambers (atria) pump blood to the lower chambers (ventricles) and to the rest of the body
With AFib, the atria quiver instead of pumping with a steady beat. This may cause blood to pool in the atria, which can lead to blood clots forming
If a blood clot, or piece of it, breaks off, it can travel out of the heart, through the blood vessels, and to the brain—where it
can cause a stroke
Since patients with AFib not caused
by a heart valve problem are at a
higher risk of stroke, it’s important
to ask your doctor about treatment
that can help reduce the
risk of stroke.
Strokes related to AFib are often more severe than strokes from other causes
Stroke is the fifth leading cause of death in the U.S.
Stroke is a leading cause of disability among Americans
Watch Ken share
how he learned
about his increased risk
of stroke due to
not caused by a heart
Ken was compensated for
his time and expenses.
You may ask
Do blood thinners increase the risk of bleeding?
Explore more about blood thinners below
BLOOD THINNERS WORK TO
Help reduce the risk of
blood clots forming in the
atria (upper chambers of
And therefore reduce the
risk of stroke due to blood
clots in the heart traveling
to the brain
Choosing a blood thinner with
For more than 60 years, patients were prescribed a blood thinner called warfarin. These days, you have more choices. Working with your doctor is the first step in learning more about AFib not caused by a heart valve problem and if ELIQUIS may be a treatment option to reduce the increased risk of stroke.
Why Blood Thinners
Blood thinners reduce the risk of “bad” blood clots that can form in the heart and then break
off and travel to the brain.
Blood thinners can also slow the formation of “good” blood clots, causing unexpected bleeding
or preventing clots that form at the site of an injury to stop the bleeding.
Because they help reduce the risk of blood clots forming, blood thinners increase
the risk of bleeding, which can be serious and rarely may lead to death.
While taking a blood thinner, you may bruise more easily and it may take longer
than usual for any bleeding to stop. Be sure to seek medical attention right away if you
have signs or symptoms of bleeding such as unexpected bleeding or bleeding that
lasts a long time. You may have a higher risk of bleeding if you take blood thinners and
take other medicines that increase your risk of bleeding.
Click here for more comprehensive information you should be aware of
about bleeding and ELIQUIS. Be sure to call your doctor or healthcare provider
right away if you fall or injure yourself, especially if you hit your head. Your doctor
or healthcare provider may need to examine you.
Take extra care using knives, scissors,
and nail clippers
Use an electric razor
Wear shoes or non-skid slippers
in the house
Use a soft toothbrush and waxed
Wear gloves when using sharp tools
or doing yard work
tell his story
of finding out he has AFib
by a heart valve
problem and how
his doctor chose ELIQUIS to
reduce his risk of stroke.
Joe was compensated for
his time and expenses.
Find out how
ELIQUIS reduces the risk of stroke for patients with AFib not caused by a heart valve problem
Explore more about ELIQUIS below
WHAT IS ELIQUIS?
ELIQUIS is a prescription blood thinner used to reduce the risk of stroke and blood clots in patients who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem. Only you and your doctor can decide if ELIQUIS is right for you.
to reduce the risk of blood
and stroke in patients
with AFib not
a heart valve problem.
In a clinical trial of patients with AFib not caused by a heart valve problem,
ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death. In another trial compared to aspirin, ELIQUIS had a modest increase in major bleeding.*
If you’re taking warfarin, consider talking to your doctor about ELIQUIS for both these reasons: ELIQUIS was proven effective to reduce the risk of stroke due to atrial fibrillation (AFib) not caused by a heart valve problem. Plus, ELIQUIS had significantly less major bleeding* than warfarin.
*Major bleeding included noticeable bleeding with at least 1 of the following—a transfusion of 2 or more units of blood; bleeding that occurred in the brain, spine, eye, inside the abdomen, around the heart, in a joint, or in a muscle, leading to damage; or fatal bleeding.
What are the possible serious side effects of ELIQUIS?
This is a list of some of the serious side effects of ELIQUIS.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:
Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:
Spinal or epidural blood clots (hematoma)
People who take ELIQUIS, and have
medicine injected into their spinal or
epidural area, or have a spinal puncture,
have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).
Your risk of developing a spinal or epidural blood clot is higher if:
If you take ELIQUIS and receive spinal anesthesia or a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding.
Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS:
A reaction to ELIQUIS itself
A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS.
Get medical help right away if you have any of the following symptoms:
Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects.
You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.
Who should not take ELIQUIS?
ELIQUIS is not for patients who:
What should I discuss with my healthcare team before starting ELIQUIS?
Talk to your healthcare team about the following:
Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.
Tell your healthcare team about all
of the medications you are taking, including:
How should I take ELIQUIS?
Take ELIQUIS exactly as prescribed by your doctor.
With or without food
Do not change your dose or stop taking ELIQUIS unless your doctor tells you to.
What if I miss a dose of ELIQUIS?
If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time.
When should I refill my prescription?
If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not
run out of ELIQUIS. Refill your prescription before
you run out. When leaving the hospital following hip or knee replacement, be sure that
you will have ELIQUIS available to avoid missing any doses.
ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you.
2.5 mg tablet
Round, with a pale yellow color
5 mg tablet
Oval, with a pale orange or pink color
Note: Images do not represent actual tablet size.
On one side of each tablet, there is a number indicating the dosage
strength of the tablet (in milligrams).
On the other side, there is a
medication identification number.
What is ELIQUIS?
ELIQUIS is a prescription medicine used to:
Reduce the risk of stroke and
blood clots in people who have
atrial fibrillation (AFib),
a type of irregular heartbeat,
not caused by a heart valve
Treat blood clots in the
veins of the legs (deep vein thrombosis – DVT) or lungs
(pulmonary embolism – PE), and
reduce the risk of them occurring again.
Reduce the risk of forming a blood clot in the legs (DVT)
and lungs (PE) of people who have just had hip or knee replacement surgery.
The product information provided in this
site is intended only for residents of the
United States. The products discussed herein may have different product labeling in
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with
a healthcare provider. All decisions
regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who
prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop
taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another
medicine to help prevent a blood clot from forming.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner
medicine that reduces blood clotting.
You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as
aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake
inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots.
Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.