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In a clinical trial of patients with AFib not caused by a heart valve problem,
ELIQUIS and other blood thinners increase the risk of bleeding, which can be serious, and rarely may lead to death. In another trial compared to aspirin, ELIQUIS had a modest increase in major bleeding.*
If you’re taking warfarin, consider talking to your doctor about ELIQUIS for both these reasons: ELIQUIS was proven effective to reduce the risk of stroke due to atrial fibrillation (AFib) not caused by a heart valve problem. Plus, ELIQUIS had significantly less major bleeding* than warfarin.
*Major bleeding included noticeable bleeding with at least 1 of the following—a transfusion of 2 or more units of blood; bleeding that occurred in the brain, spine, eye, inside the abdomen, around the heart, in a joint, or in a muscle, leading to damage; or fatal bleeding.
Questions about AFib,
stroke risk, and blood thinners?
Learn more about AFib & Stroke Risk.
ELIQUIS was studied in 2 clinical trials to evaluate stroke risk reduction in patients
with AFib not caused by a heart valve problem. Clinical trial results are important because they can help doctors consider and choose the right treatment for you based on their efficacy and
~24,000
PATIENTS PARTICIPATED IN 2 STUDIES
>11,000
PATIENTS TOOK ELIQUIS
CLINICAL TRIALS
Compared ELIQUIS to warfarin in patients with AFib not caused by
a heart valve problem. This group also had at least one additional risk factor for stroke (a prior stroke, age 75 or older, diabetes, heart failure, high blood pressure).
Compared ELIQUIS to aspirin in patients with AFib not caused by a heart valve problem who were not suitable for treatment with warfarin. This group also had at least one additional risk factor for stroke (a prior stroke, age 75 or older, diabetes, heart failure, or peripheral artery disease).
Based on the results of these clinical trials, ELIQUIS was approved to reduce the risk
of stroke and blood clots in patients with AFib not caused by a heart valve problem.
In trial 1, ELIQUIS had significantly less major bleeding than warfarin. In trial 2, ELIQUIS had a modest increase in major bleeding compared to aspirin.
“
When I asked my doctor if I needed to keep taking a blood thinner, we spoke about the clinical trial results and how ELIQUIS reduces stroke risk for patients with AFib not caused by a heart valve problem. It was good for me to see this information for myself.
BITSY, A REAL ELIQUIS PATIENT
Bitsy was diagnosed with AFib not caused by a heart valve problem.
She was compensated for her time and expenses.
”
SELECTED IMPORTANT SAFETY INFORMATION
For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin, heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any
Please read additional Important Safety Information, including Boxed WARNINGS below.
It's important for you and your doctor to discuss your lifestyle when choosing a blood thinner.
Here are some other things to know about taking ELIQUIS.
With ELIQUIS there are no known dietary restrictions or watch-outs for foods like
leafy greens.
Patients taking ELIQUIS do not have to go for routine INR* blood testing.
*International Normalized Ratio
To understand how ELIQUIS compares to warfarin in other areas, be sure to discuss INR blood testing or foods to watch out for with your doctor.
Keep in mind that warfarin and ELIQUIS are both prescription medicines. Only your doctor can decide which blood thinner is right for you.
“
I was resistant, because I know that with warfarin you have to go regularly to have INR blood tests. I told my doctor my concerns and he recommended ELIQUIS, which does not require regular blood testing.
WILLIAM, A REAL ELIQUIS PATIENT
William was diagnosed with AFib not caused
by a heart valve problem.
He was compensated
for his time and expenses.
”
Learn about some
possible side effects of ELIQUIS.
Watch Myra share
share her reaction
to learning she has AFib not
caused by a heart
valve
problem, and how she and
her doctor
chose ELIQUIS
to reduce her risk of stroke.
Myra was compensated
for her time and expenses.
Do not stop taking ELIQUIS without talking to the doctor who prescribed it to you
For patients taking ELIQUIS for atrial fibrillation: stopping
ELIQUIS increases your risk of having a stroke.
What are the possible serious side effects of ELIQUIS? This is a list of some of the serious side effects of ELIQUIS.
Bleeding
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.
You may have a higher risk of bleeding if you take ELIQUIS with other medicines that increase your risk of bleeding, such as:
Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:
Spinal or epidural blood clots (hematoma)
People who take ELIQUIS, and have
medicine injected into their spinal or
epidural area, or have a spinal puncture,
have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).
Your risk of developing a spinal or epidural blood clot is higher if:
If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding.
Tell your doctor right away if you have any of these signs or symptoms (especially in your legs and feet) when taking ELIQUIS:
A reaction to ELIQUIS itself
A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS.
Get medical help right away if you have any of the following symptoms:
Talk to your doctor about any side effect that may be bothering you or that does not go away. These are not all of the possible side effects of ELIQUIS. Call your doctor for medical advice about side effects.
You are encouraged to report any side effects to the FDA at 1-800-FDA-1088.
Who should not take ELIQUIS?
ELIQUIS is not for patients who:
What should I discuss with my healthcare team before starting ELIQUIS?
Talk to your healthcare team about the following:
Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.
Females who are able to become pregnant: talk with your healthcare provider about pregnancy planning, and your risk of severe uterine bleeding if you are treated with blood thinner medicines, including ELIQUIS.
Tell your healthcare team about all the medicines you take, including any:
How should I take ELIQUIS?
Take ELIQUIS exactly as prescribed by your doctor.
Twice daily
With or without food
Do not change your dose or stop taking ELIQUIS unless your doctor tells you to.
What if I miss a dose of ELIQUIS?
If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time.
When should I refill my prescription?
If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not
run out of ELIQUIS. Refill your prescription before
you run out. When leaving the hospital following hip or knee replacement, be sure that
you will have ELIQUIS available to avoid missing any doses.
ELIQUIS is available in two different tablets. Your doctor or healthcare provider will determine what dose is right for you.
2.5 mg tablet
Round, with a pale yellow color
5 mg tablet
Oval, with a pale orange or pink color
Note: Images do not represent actual tablet size.
On one side of each tablet, there is a number indicating the dosage
strength of the tablet (in milligrams).
On the other side, there is a
medication identification number.
What is ELIQUIS?
ELIQUIS is a prescription medicine used to:
Reduce the risk of stroke and
blood clots in people who have
atrial fibrillation (AFib),
a type of irregular heartbeat,
not
caused by a heart valve
problem.
Treat blood clots in the
veins of the legs (deep vein thrombosis – DVT) or lungs
(pulmonary embolism – PE), and
reduce the risk of them occurring again.
Reduce the risk of forming a
blood clot in the legs (DVT)
and lungs (PE) of people who
have just had hip or knee replacement surgery.
Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.
The product information provided in this
site is intended only for residents of the
United States. The products discussed herein may have different product labeling in
different countries.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with
a healthcare provider. All decisions
regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.
ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop
taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another
medicine to help prevent a blood clot from forming.
ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner
medicine that reduces blood clotting.
You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as
aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake
inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots.
Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.