For people at risk of stroke due to AFib Not Caused by a Heart Valve Problem. To Reduce the Risk of Blood Clots After Hip or Knee Replacement Surgery. For People With Deep Vein Thrombosis (DVT) & Pulmonary Embolism (PE). This site is intended for U.S. residents 18 years of age or older.

INDICATIONS

Considering ELIQUIS

Why ELIQUIS?

For people who’ve recently had hip or knee replacement surgery, ELIQUIS can help reduce the risk of developing blood clots in the legs and lungs.

ELIQUIS was approved based on 3 clinical trials versus enoxaparin (also known as LOVENOX®). These trials included:

>11,000

PEOPLE WHO UNDERWENT ELECTIVE HIP OR KNEE REPLACEMENT

5,770

PEOPLE RECEIVED ELIQUIS  

5,755

RECEIVED LOVENOX®

Clinical Trials

Hip Replacement Surgery
In a large clinical trial among patients who had just undergone hip replacement surgery, ELIQUIS was proven to reduce the risk of a blood clot forming in the legs and lungs better than LOVENOX®.

 

Knee Replacement Surgery
Based on the results of two clinical trials, ELIQUIS was also approved to reduce the risk of a blood clot forming in the legs and lungs of patients who underwent knee replacement surgery.


SEE ALSO:
Why There Is an Increased Risk for Blood Clots


Selected Important Safety Information

Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if: a thin tube called an epidural catheter is placed in your back to give you certain medicine, you take NSAIDs or a medicine to prevent blood from clotting, you have a history of difficult or repeated epidural or spinal punctures, and/or you have a history of problems with your spine or have had surgery on your spine.

If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.

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Some Frequently Asked Questions

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LOVENOX® (enoxaparin) is a blood thinner that is only available in injectable form.

Warfarin is a pill that's taken orally. Patients taking warfarin have to follow certain dietary restrictions. Warfarin also requires patients to go for routine INR blood testing to check if their levels are within the target range and to adjust their warfarin dose if they're not.

ELIQUIS is another blood thinner that can help treat DVT and PE clots and reduce the risk of them happening again. ELIQUIS can be taken with or without food, meaning taking it does not need to be timed to a meal. Unlike LOVENOX®, which is injected, ELIQUIS is taken by mouth twice daily. And unlike warfarin, ELIQUIS has no dietary restrictions and does not require routine INR blood testing.

Take ELIQUIS exactly as prescribed by your doctor. ELIQUIS is taken by mouth twice daily. The recommended dose of ELIQUIS is 2.5 mg and the initial dose is usually taken 12 to 24 hours after surgery. If you have difficulty swallowing the tablet whole, talk to your doctor about other ways to take ELIQUIS.

Your doctor will decide the duration of your treatment. The recommended dose of ELIQUIS is 2.5 mg taken by mouth twice daily. The initial dose is usually taken 12 to 24 hours after surgery.

  • In patients undergoing hip replacement surgery, the recommended duration of treatment is 35 days.
  • In patients undergoing knee replacement surgery, the recommended duration of treatment is 12 days.

How long ELIQUIS is taken varies from patient to patient. Your doctor will decide the appropriate length of treatment for you.

ELIQUIS can cause bleeding, which can be serious and rarely may lead to death.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding. Tell your doctor about all of the medicines you take.

While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

Call your doctor or get medical help right away if you have any signs or symptoms of bleeding when taking ELIQUIS.

Please click here for signs and symptoms of bleeding.

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IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.

While taking ELIQUIS, you may bruise more easily and it may take longer than usual for any bleeding to stop.

Call your doctor or get medical help right away if you have any of these signs or symptoms of bleeding when taking ELIQUIS:

  • unexpected bleeding or bleeding that lasts a long time, such as unusual bleeding from the gums, nosebleeds that happen often, or menstrual or vaginal bleeding that is heavier than normal
  • bleeding that is severe or you cannot control
  • red, pink, or brown urine; red or black stools (looks like tar)
  • coughing up or vomiting blood or vomit that looks like coffee grounds
  • unexpected pain, swelling, or joint pain
  • headaches, or feeling dizzy or weak

ELIQUIS (apixaban) is not for patients with artificial heart valves.

Spinal or epidural blood clots (hematoma). People who take ELIQUIS, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:

  • a thin tube called an epidural catheter is placed in your back to give you certain medicine
  • you take NSAIDs or a medicine to prevent blood from clotting
  • you have a history of difficult or repeated epidural or spinal punctures
  • you have a history of problems with your spine or have had surgery on your spine

If you take ELIQUIS and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots or bleeding. Tell your doctor right away if you have tingling, numbness, or muscle weakness, especially in your legs and feet.

Do not take ELIQUIS if you currently have certain types of abnormal bleeding or have had a serious allergic reaction to ELIQUIS.

Before you take ELIQUIS, tell your doctor if you have kidney or liver problems, have any other medical condition, or have ever had bleeding problems. Tell your doctor if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. You and your doctor should decide if you will take ELIQUIS or breastfeed. You should not do both.

Take ELIQUIS exactly as prescribed by your doctor. Take ELIQUIS twice every day with or without food, and do not change your dose or stop taking it unless your doctor tells you to. If you miss a dose of ELIQUIS, take it as soon as you remember, and do not take more than one dose at the same time. If you are taking ELIQUIS for atrial fibrillation, stopping ELIQUIS may increase your risk of having a stroke. Do not run out of ELIQUIS. Refill your prescription before you run out. When leaving the hospital following hip or knee replacement, be sure that you will have ELIQUIS available to avoid missing any doses.

Possible serious side effects include bleeding or a reaction to ELIQUIS itself. A reaction to ELIQUIS can cause hives, rash, itching, and possibly trouble breathing. If you get this reaction, it will usually happen soon after you take a dose of ELIQUIS. Get medical help right away if you have sudden chest pain or chest tightness, have sudden swelling of your face or tongue, have trouble breathing, wheezing, or feeling dizzy or faint.

INDICATIONS

ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation, a type of irregular heartbeat, not caused by a heart valve problem.

ELIQUIS is a prescription medicine used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again.

ELIQUIS is a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.

Please see U.S. Full Prescribing Information, including Boxed WARNINGS and Medication Guide.

LOVENOX® is a registered trademark of Aventis Pharma S.A.

This independent, non-profit organization provides assistance to qualifying patients with financial hardship who generally have no prescription insurance. Contact 1-800-736-0003 or visit www.bmspaf.org for more information.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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SELECTED IMPORTANT SAFETY INFORMATION

For people taking ELIQUIS® (apixaban) for atrial fibrillation: Do not stop taking ELIQUIS without talking to the doctor who prescribed it for you. Stopping ELIQUIS increases your risk of having a stroke.

ELIQUIS may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

You may have a higher risk of bleeding if you take ELIQUIS and take other medicines that increase your risk of bleeding, such as aspirin, nonsteroidal anti-inflammatory drugs (called NSAIDs), warfarin (COUMADIN®), heparin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), and other medicines to help prevent or treat blood clots. Tell your doctor about all of the medicines you take, including any over-the-counter medicines, vitamins, and herbal supplements.